Gwas sleep duration
WebGRIA3 [10]. In a small genome-wide association study (GWAS) of usual sleep duration in 749 Framingham Heart Study participants, no genome-wide significant associations were identified [11]. Recently, a GWAS in over 4000 individuals in seven European cohorts identified a polymorphism in ABCC9, encoding an ATP-sensitive potassium channel, that WebSep 12, 2024 · Sleep duration data were not available in ALSPAC, BiB or FinnGen, which all contributed to two-sample MR only (Fig. 1). Selection of genetic IVs for self-report sleep duration. Currently, nine GWAS of self-report sleep duration are available, with details in Additional file 1: Table S2 [2, 42,43,44,45,46,47,48,49,50,51].
Gwas sleep duration
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WebFeb 27, 2024 · Loss of PIG-Q increased sleep duration and bout length, suggesting increased sleep consolidation. A primary purpose of GWAS has been to find genes that contribute to complex diseases and facilitate drug discovery; however, the low rates of positive findings for expression-based methods that explain functional changes have … WebOct 9, 2024 · Sleep quality is a complex phenotype that is defined as a construct of sleep duration, sleep latency, number of arousals during sleep, and sleep ... We first performed a primary discovery GWAS of sleep quality measured by the PSQI in the OPPERA cohort. The OPPERA cohort was comprised of self-declared non-Hispanic whites (NHW, …
WebOct 1, 2016 · Another GWAS including seven European samples (total N = 4,251) identified an intronic genetic variant within ABCC9 (i.e., rs1104205) associated with sleep duration, 34 but the result could not be replicated in an independent sample of young adults (N = 952). 35 Recently, a large GWAS meta-analysis of 47,180 individuals of European … WebMay 10, 2024 · View Source with insomnia, including those related to sleep quality, duration, and timing. GWAS analyze the genetic makeup of tens of thousands of people …
WebMar 7, 2024 · Genetic risk scores for sleep duration, short sleep and long sleep were tested using the weighted genetic risk score calculated by summing the products of the … WebMar 7, 2024 · Sleep is essential for homeostasis and insufficient or excessive sleep are associated with adverse outcomes. Here, the …
WebTwo SNPs were in KIF26B, which encodes the Kinesin Family Member 26 B. Kinesins are transporters of membranous organelles in mammalian neurons. 43 In a GWAS of sleep duration, KIF26B was reportedly associated with a short sleep duration of fewer than 6 hours. 44 In addition, Hautakangas et al performed a genome-wide meta-analysis of …
WebApr 6, 2024 · A GWAS for dichotomized sleep duration was performed to be consistent with our categorization strategy. IGAP meta-analysed GWAS datasets consisted of 21,982 Alzheimer’s disease ... deerfield beach marine weatherWebApr 1, 2024 · To date, the majority have focused on self-reported sleep duration, but in recent years genome-wide association studies of objectively-measured sleep have emerged. These genetic studies have discovered multiple common genetic variants and as such, have provided insight into potential biological pathways, causal relationships … deerfield beach live taxicamWebGWAS is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms GWAS - What does GWAS stand for? The Free Dictionary deerfield beach live cam floridaWebApr 1, 2024 · To date, the majority have focused on self-reported sleep duration, but in recent years genome-wide association studies of objectively-measured sleep have … deerfield beach mesothelioma lawyerWebDec 10, 2024 · No other findings were confirmed from previous GWAS that relied on self-report measures of physical activity and sleep duration. To account for the likely non … deerfield beach live cam fishing pierWebDec 10, 2024 · Recent GWAS have also reported common variants that are associated with sleep duration in UK Biobank 10,11,12. However, GWAS of behavioural traits such as … deerfield beach map locationWebA GWAS was performed in a Finnish sample (n = 1941), and variants with suggestive association (P < 5 × 10 −5) were tested in a follow-up sample from the same population with sleep duration (n = 6834) and time in bed (n = 1720). Variants with pointwise association of P < 0.05 in the follow-up sample were analysed further. deerfield beach live cams